EXAMINE THIS REPORT ON SDZ 220-040

The impairment of HMGB1 perform leads to enhanced mitochondrial DNA destruction. During the SCA1 mouse model, more than-expression on the HMGB1 protein through an released virus vector bearing the HMGB1 gene facilitates repair in the mitochondrial DNA destruction, ameliorates the neuropathology and also the motor deficits, and extends the lifespan